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Non-intercalative and sequence-selective interaction of nitropyrene/acridine-skeleton with nucleotides: application
M Shichita1, R Shimazawa, O Nakajima
1Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
Biological & Pharmaceutical Bulletin
|April 1, 1995
Abstract:
Water-insoluble typical intercalators, acridine and pyrene, were converted to water-soluble species, Dex-Pyr and Dex-Acr, respectively, by coupling with dextran polymer. By the use of these dextran-coupled intercalators, interactions of acridine- and pyrene-skeletones with various nucleotides in aqueous solutions were analyzed.