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Related Experiment Videos

Superovulation, IGFBP-1 and birth weight

M R Johnson1, R Irvine, F Hills

  • 1Academic Department of Obstetrics and Gynaecology, Chelsea and Westminister Hospital, London, UK.

European Journal of Obstetrics, Gynecology, and Reproductive Biology
|April 1, 1995
PubMed
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Superovulation using buserelin and human menopausal gonadotrophin (b/hMG) increases insulin-like growth factor binding protein-1 (IGFBP-1) in late pregnancy. This may contribute to the observed lower birth weights in pregnancies achieved with b/hMG.

Area of Science:

  • Reproductive Endocrinology
  • Maternal-Fetal Medicine
  • Biochemistry

Background:

  • Superovulation protocols are widely used for in-vitro fertilization (IVF).
  • Insulin-like growth factor binding protein-1 (IGFBP-1) is an important pregnancy-associated protein.
  • The impact of specific superovulation regimens on IGFBP-1 levels and pregnancy outcomes requires further investigation.

Purpose of the Study:

  • To investigate the effect of superovulation on circulating insulin-like growth factor binding protein-1 (IGFBP-1) levels.
  • To compare IGFBP-1 levels and pregnancy outcomes between natural conception, and pregnancies achieved via IVF-ET following different superovulation protocols.

Main Methods:

  • Measurement of serum IGFBP-1 levels in singleton pregnancies.
  • Comparison between naturally conceived pregnancies (n=203), and those following IVF-ET with buserelin/human menopausal gonadotrophin (b/hMG) (n=15) or clomiphene citrate/hMG (CC/hMG) (n=15).

Related Experiment Videos

  • Analysis of birth weight and gestational age at delivery.

    • Main Results:

    • Circulating IGFBP-1 levels were similar across all groups in the first trimester.
    • IGFBP-1 levels were similar in natural and b/hMG pregnancies in the second trimester.
    • Third-trimester IGFBP-1 levels were significantly higher in b/hMG pregnancies (P=0.0002).
    • Birth weights were significantly lower in the b/hMG group (P=0.04) but not the CC/hMG group.
    • Gestational age was reduced in CC/hMG pregnancies (P=0.04) but similar in b/hMG and control pregnancies.

    Conclusions:

    • Pregnancies achieved with b/hMG superovulation show elevated third-trimester IGFBP-1 levels.
    • Reduced birth weight is associated with b/hMG superovulation.
    • These findings suggest a potential link between altered IGFBP-1 and adverse pregnancy outcomes following specific superovulation protocols.