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Vascular permeability factor, tumor angiogenesis and stroma generation
D R Senger1, L F Brown, K P Claffey
1Department of Pathology, Beth Israel Hospital, Boston, MA 02215, USA.
Invasion & Metastasis
|January 1, 1994
Summary
Vascular permeability factor (VPF/VEGF) is a cytokine that promotes tumor growth by increasing blood vessel permeability and stimulating endothelial cell growth. It also plays a role in wound healing and rheumatoid arthritis.
Area of Science:
- Molecular Biology
- Cell Biology
- Oncology
Background:
- Vascular permeability factor (VPF/VEGF) is a cytokine that regulates endothelial cell function.
- It interacts with high-affinity tyrosine kinase receptors.
- VPF/VEGF is implicated in both tumor biology and nonmalignant processes.
Purpose of the Study:
- To elucidate the roles of VPF/VEGF in tumor biology and related conditions.
- To understand the mechanisms by which VPF/VEGF affects endothelial cells.
Main Methods:
- The study focuses on the known functions and interactions of VPF/VEGF.
- Analysis of VPF/VEGF's effects on endothelial cells (ECs) and microvasculature.
Main Results:
- VPF/VEGF activates phospholipase C and induces intracellular calcium ([CA2+]i) transients in ECs.
- It increases microvascular permeability, aiding tumor extracellular matrix modification.
- VPF/VEGF acts as a selective mitogen for ECs, promoting new blood vessel growth.
Conclusions:
- VPF/VEGF is crucial for tumor angiogenesis and extracellular matrix remodeling.
- Its roles extend to nonmalignant conditions like wound healing and rheumatoid arthritis.
- VPF/VEGF is a key mediator in processes involving new blood vessel formation.