Effect of chronic physical exercise on cholesterol biosynthesis in meal-fed rats

Chronic physical exercise (in a rotating drum) influenced liver cholesterologenesis (from acetate-l-14C) in vivo in meal-fed rats (for 2 hours daily) in close temporary correlation with the time of realimentation. If always performed just prior to feeding physical exercise blocks the development of adaptive hyperchloesterologenesis as a metabolic response to infrequent feeding. If it is performed 3 and a half hours after realimentation, the stimulating effect of infrequent feeding on liver cholesterologenesis is not modified.