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Does endotoxin stimulate cells by mimicking ceramide?
1Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021, USA.
Immunology Today
|June 1, 1995
Abstract:
Recent studies indicate that tumor necrosis factor (TNF) and interleukin 1 (IL-1) stimulate cells via the intracellular messenger ceramide. Bacterial endotoxin (lipopolysaccharide; LPS) shows strong structural and functional resemblance to ceramide. Here, Samuel Wright and Richard Kolesnick review data suggesting that LPS may provoke cellular responses by mimicking the action of ceramide.