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Related Experiment Videos

Angiogenic factors stimulate mast-cell migration

B L Gruber1, M J Marchese, R Kew

  • 1Department of Medicine, SUNY at Stony Brook 11794-8161, USA.

Blood
|October 1, 1995
PubMed
Summary

Angiogenic factors like PDGF-AB, VEGF, and bFGF attract mast cells to new blood vessel sites. These factors may recruit mast cells, aiding new vessel formation through cell interactions.

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Area of Science:

  • Cell Biology
  • Angiogenesis Research
  • Immunology

Background:

  • Mast cells are found at sites of angiogenesis.
  • The specific factors recruiting mast cells to these sites are not well-defined.

Purpose of the Study:

  • To investigate whether angiogenic factors induce mast cell chemotaxis.
  • To identify specific angiogenic factors responsible for mast cell recruitment.

Main Methods:

  • Assessing directed migration of murine mast cells in response to various angiogenic factors.
  • Utilizing checkerboard analysis to differentiate chemotaxis from chemokinesis.
  • Investigating cross-desensitization and the effects of tyrosine kinase inhibitors and pertussis toxin.

Main Results:

  • Platelet-derived growth factor-AB (PDGF-AB), vascular endothelial cell growth factor (VEGF), and basic fibroblast growth factor (bFGF) induced directed mast cell migration.
  • Platelet-derived endothelial cell growth factor (PD-ECGF) induced chemokinesis, while tumor necrosis factor-alpha showed chemotactic activity.
  • Epidermal growth factor (EGF) did not induce mast cell migration; genistein inhibited responses, but pertussis toxin did not.

Conclusions:

  • Angiogenic factors can simultaneously stimulate endothelial cells and recruit mast cells.
  • Mast cell accumulation at angiogenic sites may facilitate new vessel formation.
  • Specific growth factors play distinct roles in mast cell recruitment and migration patterns.

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