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Related Experiment Video

Updated: Jul 25, 2026

Induction of Mouse Lung Injury by Endotracheal Injection of Bleomycin
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Induction of Mouse Lung Injury by Endotracheal Injection of Bleomycin

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Controlled release of poly-D,L-lactic acid containing bleomycin

K Nakamura1, S Natsugoe, T Kumanohoso

  • 1Department of Pharmacy, Kagoshima University School of Medicine, Japan.

Anti-Cancer Drugs
|June 1, 1995
PubMed
Summary

New polylactic acid (PLA) polymers offer controlled bleomycin (BLM) release for anti-cancer applications. These solid forms show sustained drug delivery over 3-6 weeks without an initial burst, suggesting potential for targeted cancer therapy.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Cancer Therapeutics

Background:

  • Bleomycin (BLM) is an anti-cancer drug requiring controlled delivery.
  • Polylactic acid (PLA) is a biodegradable polymer with potential for drug encapsulation.

Purpose of the Study:

  • To develop and evaluate polylactic acid (PLA) solid forms containing bleomycin (BLM).
  • To investigate the in vitro release kinetics of BLM from different molecular weight PLA polymers.

Main Methods:

  • Preparation of BLM-containing PLA polymers using melt-pressing technique.
  • Testing four types of PLA with varying molecular weights (1500DL, 2200DL, 2800DL, 3500DL) and a mixture.
  • In vitro drug release studies in an immersion system.

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A Refined Aerosol-Based Intratracheal Bleomycin Delivery Method for Reproducible and Minimally Invasive Mouse Models of Pulmonary Fibrosis
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Last Updated: Jul 25, 2026

Induction of Mouse Lung Injury by Endotracheal Injection of Bleomycin
06:52

Induction of Mouse Lung Injury by Endotracheal Injection of Bleomycin

Published on: April 30, 2019

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis
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Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis

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A Refined Aerosol-Based Intratracheal Bleomycin Delivery Method for Reproducible and Minimally Invasive Mouse Models of Pulmonary Fibrosis
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A Refined Aerosol-Based Intratracheal Bleomycin Delivery Method for Reproducible and Minimally Invasive Mouse Models of Pulmonary Fibrosis

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Main Results:

  • All prepared PLA polymers demonstrated controlled BLM release, with less than 5% cumulative release by day three.
  • No initial burst release of BLM was observed from any of the polymer formulations.
  • Sustained BLM release was achieved over periods ranging from 3 to 6 weeks.

Conclusions:

  • PLA polymers are effective in creating solid forms for controlled bleomycin delivery.
  • These novel BLM-containing polymers show promise for localized drug administration and sustained anti-cancer release patterns.