Related Experiment Video

Updated: May 5, 2026

A Protocol for Analyzing Hepatitis C Virus Replication
13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

23.7K

High prevalence of hepatitis C in Egyptian patients with chronic liver disease

I A Waked1, S M Saleh, M S Moustafa

  • 1Department of Medicine, Liver Institute, Menoufia University, Shibin El Kom, Egypt.

Gut
|July 1, 1995
PubMed

Insights

Hepatitis C virus (HCV) is the leading cause of chronic liver disease in Egypt, affecting over 73% of patients. This study highlights the urgent need to understand HCV transmission routes in the region.

Area of Science:

  • Hepatology
  • Virology
  • Public Health

Background:

  • Egypt reports the world's highest prevalence of hepatitis C virus (HCV) infection.
  • Previous studies have not established HCV as a primary cause of chronic liver disease (CLD) in Egypt.

Purpose of the Study:

  • To determine the prevalence of HCV and hepatitis B virus (HBV) in patients with CLD in Egypt.
  • To investigate the association between HCV and CLD, including cirrhosis and hepatocellular carcinoma (HCC).

Main Methods:

  • Serological testing for HCV antibodies and HBV surface antigen in 1023 patients with CLD.
  • Histopathological examination of liver biopsies in 100 patients.
  • Correlation analysis of HCV prevalence with schistosomiasis and HBV status.

Main Results:

  • HCV antibodies were detected in 73.5% of CLD patients, significantly higher than HBV surface antigen (16.4%).
  • HCV was more prevalent in patients with active schistosomiasis and without HBV.
  • HCV was present in 84.3% of patients with biopsy-confirmed chronic hepatitis, cirrhosis, or HCC.

Conclusions:

  • Hepatitis C is the predominant cause of chronic liver disease in Egypt.
  • These findings underscore the critical need for research into HCV transmission pathways in Egypt.
  • Effective public health strategies are required to control the hepatitis C epidemic in Egypt.

More Related Videos

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks10:28

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

9.4K
Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection04:11

Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection

Published on: December 15, 2023

5.5K

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
382
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
271
Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
86
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion...
25
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
28
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to...
42