Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Positive selection of T cells

B J Fowlkes1, E Schweighoffer

  • 1Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, USA.

Current Opinion in Immunology
|April 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

William E. Paul, MD (1936-2015).

Trends in immunology·2016
Same author

William E. Paul, M.D. (1936–2015).

Immunity·2016
Same author

Notch signaling regulates antigen sensitivity of naive CD4+ T cells by tuning co-stimulation.

Immunity·2015
Same author

Novel INHAT repressor (NIR) is required for early lymphocyte development.

Proceedings of the National Academy of Sciences of the United States of America·2014
Same author

Kinase suppressor of Ras 1 is required for full ERK activation in thymocytes but not for thymocyte selection.

European journal of immunology·2010
Same author

Amyloid precursor family proteins are expressed by thymic and lymph node stromal cells but are not required for lymphocyte development.

International immunology·2009

Recent technical advances illuminate mechanistic aspects of T cell positive selection. Key findings include the structure of the pre-T cell receptor, mediating cell types, and peptide roles in thymic selection.

Area of Science:

  • Immunology
  • T cell development

Background:

  • Positive selection is a critical process in T cell development within the thymus.
  • Understanding the mechanistic features of positive selection is crucial for immune system function.

Purpose of the Study:

  • To investigate the mechanistic features of T cell positive selection.
  • To explore the role of peptides in thymic selection.

Main Methods:

  • Analysis of the early pre-T cell receptor structure and function.
  • Identification of cell types mediating positive selection.
  • Assessment of MHC and co-receptor contributions to CD4/CD8 lineage commitment.

Main Results:

  • Significant progress in understanding the pre-T cell receptor.

Related Experiment Videos

  • Defined specific cell types involved in positive selection.
  • Elucidated the role of peptides in thymic selection processes.

    • Conclusions:

    • Technical advancements have enabled deeper mechanistic insights into positive selection.
    • Peptide involvement is a key factor in thymic selection and T cell development.