Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

New methods to predict MHC-binding sequences within protein antigens

J Hammer1

  • 1Roche Milano Ricerche, Italy.

Current Opinion in Immunology
|April 1, 1995
PubMed
Summary

Predicting sequences that bind to human Major Histocompatibility Complex (MHC) molecules is crucial for immunology. New methods allow for complex motif analysis, aiding the design of therapeutic peptides.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Temporal order of activations and interactions during arithmetic calculations measured by intracranial electrophysiological recordings in the human brain.

Scientific reports·2026
Same author

Hohlraum Reheating from Burning NIF Implosions.

Physical review letters·2024
Same author

[Myalgia and fever in a 35-year-old woman].

La Revue de medecine interne·2023
Same author

Tunable and state-preserving frequency conversion of single photons in hydrogen.

Science (New York, N.Y.)·2022
Same author

Interpretable functional specialization emerges in deep convolutional networks trained on brain signals.

Journal of neural engineering·2022
Same author

Twist and strain tuning of third harmonic generation in glass nanostrand with two sub-wavelength hollow channels.

Optics letters·2021

Area of Science:

  • Immunology
  • Computational Biology
  • Bioinformatics

Background:

  • Predicting Major Histocompatibility Complex (MHC)-binding sequences in protein antigens is fundamental to immunological research.
  • Understanding these interactions is key to developing effective vaccines and immunotherapies.

Purpose of the Study:

  • To analyze and predict MHC-binding sequences within protein antigens.
  • To characterize MHC-binding motifs for all human MHC alleles.

Main Methods:

  • Utilizing recent advances in computational immunology.
  • Analyzing complex MHC-binding motifs for both Class I and Class II MHC molecules.

Main Results:

  • Developed methods for predicting MHC-binding sequences with increased accuracy.
  • Enabled the systematic characterization of binding motifs across diverse human MHC alleles.

Conclusions:

  • The ability to predict MHC-binding sequences is central to modern immunology.
  • Systematic characterization of MHC-binding motifs will accelerate the design of novel therapeutic peptides.

Related Experiment Videos