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Analysis of immunoglobulin gene rearrangements in single B cells
Current Opinion in Immunology
|April 1, 1995
Abstract:
The polymerase chain reaction allows the characterization of RNA and DNA sequences in samples as small as a single cell. The recent development of amplification systems designed to isolate rearranged immunoglobulin genes from single B lineage cells has provided a powerful tool to investigate various aspects of B-cell development.