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T helper cell differentiation in immune response

S L Reiner1, R A Seder

  • 1Gwenn Knapp Center for Lupus and Immunology Research, Department of Medicine, University of Chicago, IL 60637-5420, USA.

Current Opinion in Immunology
|June 1, 1995
PubMed

Significant progress has been made in understanding the maturation of antigen-specific CD4+ T helper cell responses. Recent progress centers on the network of cytokines, accessory molecules, and cell types that shapes the differentiation of distinct T helper cell subsets. Use of transgenic and knockout mice and well characterized in vivo models have helped clarify the interdependence or independence of many of these complex factors.

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