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Two flavone 2'-glucosides from Scutellaria baicalensis

K Ishimaru1, K Nishikawa, T Omoto

  • 1Department of Applied Biological Sciences, Faculty of Agriculture, Saga University, Japan.

Phytochemistry
|September 1, 1995
PubMed
Summary

Researchers isolated two novel flavone glucosides and seven other phenolics from Scutellaria baicalensis roots. These compounds, including new glucosides and known flavonoids, expand our understanding of this plant

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Area of Science:

  • Phytochemistry
  • Natural Product Chemistry
  • Pharmacognosy

Background:

  • Scutellaria baicalensis (Chinese skullcap) is a traditional medicinal herb.
  • Its roots are known to contain various bioactive compounds, primarily flavonoids.
  • Previous research has identified numerous compounds, but ongoing exploration is crucial for new discoveries.

Purpose of the Study:

  • To isolate and characterize novel compounds from the roots of Scutellaria baicalensis.
  • To identify and confirm the structures of previously known phenolic compounds present in the extract.
  • To contribute to the phytochemical knowledge base of Scutellaria baicalensis.

Main Methods:

  • Extraction of Scutellaria baicalensis roots using aqueous methanol.
  • Chromatographic techniques (e.g., column chromatography, HPLC) for compound isolation.

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  • Spectroscopic methods (e.g., NMR, Mass Spectrometry) for structural elucidation.

    • Main Results:

    • Isolation of two new flavone glucosides: 5,2',6'-trihydroxy-6,7,8-trimethoxyflavone 2'-O-glucoside and 5,2',6'-trihydroxy-6,7-dimethoxyflavone 2'-O-glucoside.
    • Identification of seven known phenolic compounds: 5,7,2',6'-terahydroxyflavone, 5,7,2',5'-tetrahydroxy-8,6'-dimethoxyflavone, skullcapflavone II, baicalin, baicalin methyl ester, wogonin 7-glucuronide, and 3,5,7,2',6'-pentahydroxyflavanone.
    • Structural confirmation of all isolated compounds through comprehensive spectroscopic analysis.

    Conclusions:

    • The study successfully identified two previously undescribed flavone glucosides from Scutellaria baicalensis roots.
    • A total of nine phenolic compounds were isolated and characterized, enriching the phytochemical profile of the plant.
    • These findings contribute to the understanding of Scutellaria baicalensis's chemical constituents and may inform future research into their biological activities.