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Laryngeal cryptococcus. Treatment with oral fluconazole
J E Kerschner1, M B Ridley, J N Greene
1Division of Otolaryngology-Head and Neck Surgery, University of South Florida, Tampa, USA.
Archives of Otolaryngology--Head & Neck Surgery
|October 1, 1995
Summary
This study reports the first successful treatment of laryngeal Cryptococcus neoformans infection using oral fluconazole. The antifungal agent was used as a single treatment for a patient with chronic obstructive pulmonary disease.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Otolaryngology
Background:
- Cryptococcus neoformans is an opportunistic fungal pathogen.
- Laryngeal cryptococcosis is a rare manifestation, particularly in immunocompromised patients.
- Chronic obstructive pulmonary disease (COPD) patients on glucocorticosteroids are at increased risk for opportunistic infections.
Observation:
- A case of laryngeal Cryptococcus neoformans infection was identified.
- The patient was dependent on glucocorticosteroids for management of COPD.
- The infection presented as a laryngeal mass.
Findings:
- Successful treatment of laryngeal cryptococcosis was achieved.
- Oral fluconazole was administered as a single therapeutic agent.
- This represents the first reported instance of successful monotherapy with oral fluconazole for this condition.
Implications:
- Oral fluconazole can be an effective single-agent treatment for laryngeal cryptococcosis.
- This finding offers a potentially less invasive treatment option for selected patients.
- Highlights the importance of considering opportunistic fungal infections in immunocompromised individuals with respiratory conditions.