[Glioblastoma multiforme with liver metastasis--case report]

Area of Science:

• Neuro-oncology
• Pathology
• Radiology

Background:

• Glioblastoma multiforme (GBM) is an aggressive primary brain tumor.
• Extracranial metastasis from GBM is exceptionally uncommon.
• Understanding rare metastatic patterns is crucial for comprehensive patient care.

Observation:

• An autopsy case report of a 42-year-old female with GBM.
• Initial presentation included headache, with imaging revealing a left parietooccipital tumor.
• Despite subtotal resection and adjuvant therapy, the patient developed spinal dissemination and liver metastasis.

Findings:

• Microscopic confirmation of glioblastoma multiforme.
• Postmortem examination revealed local recurrence, subarachnoidal dissemination, and hepatic metastasis.
• No lung or lymph node metastasis was identified.

Implications:

• This case highlights an unusual hepatic metastasis pathway in GBM.
• The vertebral-portal venous system anastomosis is implicated as the likely route.
• Further research into rare GBM metastatic patterns may improve diagnostic and therapeutic strategies.