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Persistent electrocardiographic changes after flecainide overdose

J Greig1, B M Groden

  • 1Royal Infirmary, Glasgow.

The British Journal of Clinical Practice
|July 1, 1995
PubMed
Summary
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Overdosing with flecainide acetate, a class 1C antiarrhythmic, is uncommon. This case report details a rare overdose leading to severe arrhythmias and prolonged ECG changes in a patient undergoing long-term therapy.

Area of Science:

  • Pharmacology
  • Cardiology
  • Clinical Toxicology

Background:

  • Flecainide acetate is a potent Class IC antiarrhythmic drug used for managing cardiac arrhythmias.
  • Overdosage of flecainide acetate is considered rare, especially in patients on long-term therapeutic regimens.

Observation:

  • A rare case of flecainide acetate overdosage occurred in a patient receiving long-term treatment.
  • The overdose resulted in significant and life-threatening cardiac arrhythmias.
  • Prolonged and severe electrocardiographic abnormalities were noted following the overdose.

Findings:

  • Flecainide acetate overdose can precipitate severe ventricular and supraventricular arrhythmias.
  • Electrocardiographic manifestations of flecainide acetate toxicity include QRS widening, QT interval prolongation, and heart block.

Related Experiment Videos

  • The duration of these abnormalities can be prolonged, posing a significant clinical challenge.

    • Implications:

    • This case underscores the potential for serious toxicity even with rare overdoses of flecainide acetate.
    • Clinicians should maintain a high index of suspicion for flecainide acetate toxicity in patients presenting with unexplained arrhythmias, particularly those on long-term therapy.
    • Prompt recognition and management are crucial for mitigating life-threatening consequences of flecainide acetate overdosage.