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Food allergy and asthma

L Businco1, P Falconieri, P Giampietro

  • 1Department of Pediatrics, University La Sapienza, Rome, Italy.

Pediatric Pulmonology. Supplement
|January 1, 1995
PubMed
Summary

Food allergy can cause wheezing in children, especially those with atopic dermatitis. Careful assessment for food allergy is crucial in asthmatic children with these features.

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Area of Science:

  • Allergy and Immunology
  • Pediatric Respiratory Medicine

Background:

  • Food allergy (FA) is a known cause of atopic dermatitis (AD) and anaphylaxis, but its link to asthma is less understood.
  • Wheezing as a unique symptom of FA is rare, and food-induced wheezing prevalence is not well-established.
  • Most food-induced asthma cases occur in children, often linked to IgE-mediated responses.

Purpose of the Study:

  • To investigate the role of food allergy in childhood asthma.
  • To assess the prevalence and characteristics of food-induced wheezing.
  • To evaluate the diagnostic utility of double-blind, placebo-controlled oral food challenges (DBPCOFC) in identifying food-induced asthma.

Main Methods:

  • Reviewing literature on food allergy and respiratory symptoms.
  • Analyzing data on children with asthma, AD, and elevated IgE.
  • Conducting DBPCOFC in children with suspected food-induced asthma, particularly cow's milk allergy.

Main Results:

  • A significant proportion of children with IgE-mediated cow's milk allergy developed asthma symptoms after DBPCOFC.
  • Children with asthma and AD, or elevated total serum IgE, are at higher risk for FA.
  • Food allergy can trigger respiratory symptoms via ingestion or inhalation.

Conclusions:

  • Food allergy should be carefully assessed in children with asthma, particularly those with a history of AD and/or elevated IgE.
  • DBPCOFC is a valuable tool for diagnosing food-induced asthma.
  • IgE-mediated food allergies, like cow's milk allergy, can precipitate asthma in susceptible children.

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