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Intracranial hemangiopericytomas in children
C E Herzog1, N E Leeds, J M Bruner
1Divisions of Pediatrics, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
Pediatric Neurosurgery
|January 1, 1995
Summary
Infantile hemangiopericytomas (HPs) are rare pediatric brain tumors. Neonatal HPs treated with surgery alone show improved outcomes and reduced recurrence risk.
Area of Science:
- Pediatric Oncology
- Neurosurgery
- Tumor Biology
Background:
- Hemangiopericytomas (HPs) are rare tumors, with approximately 10% occurring in pediatric populations.
- Intracranial hemangiopericytomas present unique diagnostic and therapeutic challenges in children.
Observation:
- Two pediatric cases of intracranial hemangiopericytoma were treated with surgery alone at our institution.
- A literature review identified four additional infantile cases, with presentations ranging from 2 days to 9 months of age.
Findings:
- Infantile hemangiopericytomas demonstrate a more favorable prognosis compared to adult counterparts.
- Intracranial hemangiopericytomas in infants also exhibit an improved outcome.
- Neonatal-onset tumors treated surgically showed better prognoses, while post-neonatal tumors had higher recurrence rates.
Implications:
- Early surgical intervention for neonatal hemangiopericytomas may be curative.
- Further research is needed to understand recurrence patterns and optimize treatment for post-neonatal infantile hemangiopericytomas.
- This highlights the importance of specialized pediatric neuro-oncology care for rare tumors.