Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

International Cell Exchange, 1994

M Lau, P I Terasaki, M S Park

    Clinical Transplants
    |January 1, 1994
    PubMed
    Summary
    This summary is machine-generated.

    The 1994 International Cell Exchange demonstrated improved accuracy in human leukocyte antigen (HLA) typing for both Class I and Class II antigens. Continuous participation and retyping efforts led to enhanced detection rates and reduced discrepancies in HLA serology and DNA typing.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Geodetic Investigations of the Europa Clipper Mission.

    Space science reviews·2026
    Same author

    Cannabis in road traffic - a retrospective analysis to identify possible cut-off-values.

    Forensic science, medicine, and pathology·2025
    Same author

    Homelessness, type of homelessness, and risk of cause-specific mortality: a systematic review and meta-analysis of 116 studies comprising 2,563,633 homeless people and 129,292,553 population controls.

    medRxiv : the preprint server for health sciences·2025
    Same author

    Corrigendum correcting the paper 'Observational study on the neonatal outcome during the COVID-19 pandemic in Germany'.

    Acta paediatrica (Oslo, Norway : 1992)·2024
    Same author

    Preventing Teen Pregnancy: A Qualitative Study of the Perspectives of Parenting and Expecting Latino Adolescents.

    Journal of pediatric and adolescent gynecology·2023
    Same author

    Observational study on the neonatal outcome during the COVID-19 pandemic in Germany.

    Acta paediatrica (Oslo, Norway : 1992)·2023
    Same journal

    Clinical Relevance of Donor-Specific IgM Antibodies in HLA Incompatible Renal Transplantation: A Retrospective Single-Center Study.

    Clinical transplants·2017
    Same journal

    Influenza Immunization and the Generation of Anti-HLA and Anti-MICA Antibodies in Patients with Renal Failure and in Kidney Transplant Recipients.

    Clinical transplants·2017
    Same journal

    From Accurate Assessment of Anti-HLA Antibody MFI to Complement-Binding Assays.

    Clinical transplants·2017
    Same journal

    Post-transplant Desensitization for Deceased Donor Kidney Transplant Recipients: A Single Center Experience.

    Clinical transplants·2017
    Same journal

    Acute Rejection in 6-Antigen HLA-Matched Kidney Transplant Recipients: Risk Factors and Outcomes from the Wisconsin Allograft Recipient Database (WisARD).

    Clinical transplants·2017
    Same journal

    C1q Donor-Specific Antibody Associates with Post-transplant Biopsy Findings in Highly- Sensitized Kidney Transplant Recipients.

    Clinical transplants·2017
    See all related articles

    Area of Science:

    • Immunogenetics and Histocompatibility
    • Molecular Biology and Genetics
    • Clinical Laboratory Science

    Background:

    • The International Cell Exchange program facilitates standardized human leukocyte antigen (HLA) typing.
    • Accurate HLA typing is critical for organ transplantation and disease association studies.
    • Previous assessments highlighted variability in typing accuracy across laboratories.

    Purpose of the Study:

    • To summarize the results of the 1994 International Cell Exchange for Class I and Class II HLA antigens.
    • To compare serologic and DNA-based typing methods for Class II antigens.
    • To evaluate typing accuracy, detection levels, and discrepancy rates for specific HLA loci.

    Main Methods:

    • Analysis of typing data from 281 laboratories for Class I antigens and 119/74 laboratories for Class II serologic/DNA typing.

    Related Experiment Videos

  • Determination of average and high detection levels for 16 A-locus and 27 B-locus antigens.
  • Comparison of discrepancy rates for frequently typed A-locus and B-locus antigens, including false-negative and false-positive rates.

    • Main Results:

    • High detection rates (≥95%) were achieved for most A-locus (12/16) and B-locus (10/27) antigens.
    • Lower agreement (<80%) was observed for specific antigens, including A74 and several B-locus antigens (e.g., B46, B75).
    • False-negative rates were higher for B-locus than A-locus antigens, with B62 showing the highest false-positive rate; B70 discrepancy rates decreased over time.
    • Significant improvements in antigen detection were noted upon retyping reference cells and long-term donor typing.
    • Updated sequences for Class I exchange cells and identified variants in both Class I and Class II specificities were reported.

    Conclusions:

    • The 1994 International Cell Exchange demonstrated overall high accuracy in HLA typing, with notable improvements over time.
    • Continuous participation and re-evaluation of typing methods enhance antigen detection and reduce errors.
    • The program provides valuable data for refining HLA typing protocols and understanding genetic diversity.