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Sydenham's chorea and schizophrenia: a case report

M F Casanova1, K A Crapanzano, G Mannheim

  • 1Medical College of Georgia, Augusta 30910, USA.

Schizophrenia Research
|July 1, 1995
PubMed
Summary

Sydenham's chorea patients developing schizophrenia may have mineral deposits in the basal ganglia. This finding suggests neuroimaging may aid in identifying and managing psychotic symptoms in these movement disorder patients.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Neuropathology

Background:

  • Sydenham's chorea is a childhood disorder associated with rheumatic fever.
  • Schizophrenia is a chronic mental disorder characterized by psychosis.
  • Subcortical mineral deposition, particularly iron, is implicated in neurological and psychiatric conditions.

Observation:

  • A case report details a patient with Sydenham's chorea who later developed schizophrenia.
  • Autopsy revealed mineral deposits within the basal ganglia of the affected patient.
  • These deposits, especially iron, are linked to dopaminergic abnormalities.

Findings:

  • The patient exhibited schizophreniform symptoms and abnormal movement disorders.
  • Psychosis in such cases can be treatment-resistant to standard neuroleptics.

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  • Mineral deposition in basal ganglia may be a key neuropathological finding.

    • Implications:

    • Neuroimaging techniques like CT or MRI scans could be valuable screening tools.
    • Early detection of psychotic symptoms in Sydenham's chorea patients is crucial.
    • Understanding the link between mineral deposits and psychosis may lead to novel therapeutic strategies.