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HLA-G deletion polymorphism and pre-eclampsia/eclampsia
K E Humphrey1, G A Harrison, D W Cooper
1School of Biological Sciences, Macquarie University, Sydney, Australia.
Objective:
To investigate a HLA-G deletion polymorphism in pre-eclamptic pedigrees and the general population.
Design:
A population association study of HLA-G genotypes from pre-eclamptic/eclamptic patients and control groups.
Setting:
Analyses undertaken in the School of Biological Sciences, Macquarie University. Patients were from Royal Women's Hospital, Melbourne, and controls were from Westmead Hospital and Macquarie University, Sydney.
Subjects:
One hundred and ninety-six individuals, consisting of 29 pre-eclamptic/eclamptic (PE/E) patients, 13 individuals born of a PE/E pregnancy, 46 blood relatives of PE/E patients, 21 husbands of PE/E patients, 25 women normotensive in first pregnancy, 15 husbands of women normotensive in first pregnancy and 47 staff and students of Macquarie University.
Results:
Genotypic and gene frequencies were not significantly different in the seven groups examined.
Conclusion:
There is no detectable relationship between susceptibility to pre-eclampsia or being born of a pre-eclamptic pregnancy and HLA-G genotype.