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Molecular cloning and sequencing of the gene encoding a sheep arginine vasopressin type 1a receptor
A M Hutchins1, P A Phillips, D J Venter
1Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia.
Biochimica Et Biophysica Acta
|September 19, 1995
Abstract:
The gene for the sheep arginine vasopressin type 1a (V1a) receptor subtype was cloned from a genomic library. The deduced amino acid sequence shows characteristics of a G-protein coupled receptor and high sequence identity to human and rat V1a receptor sequences (81% and 73%, respectively). Reverse transcription-polymerase chain reaction (RT-PCR) analysis showed a tissue distribution consistent with a type V1a receptor. The genomic DNA (7.1 kb) contains a 1586 bp intron between the putative 6th and 7th transmembrane domains.