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Related Experiment Videos

Rapid changes in thyroid function tests upon treatment of tuberculosis

A R Hill1, M F Schmidt, G C Schussler

  • 1Department of Medicine, State University of New York Health Science Center, Brooklyn 11203, USA.

Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
|June 1, 1995
PubMed
Summary

Tuberculosis treatment with drugs like rifampin increases thyroid hormone binding. This study clarifies thyroid function changes in TB patients undergoing therapy.

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Area of Science:

  • Endocrinology
  • Infectious Diseases
  • Pharmacology

Background:

  • Tuberculosis (TB) patients often exhibit altered thyroid function.
  • Conflicting reports exist regarding thyroid hormone binding in TB.
  • Antitubercular drugs may influence hepatic function and thyroid hormone binding.

Purpose of the Study:

  • To investigate if antituberculosis drugs increase serum thyroxine-binding globulin (TBG).
  • To resolve discrepancies in reported thyroid function during TB treatment.

Main Methods:

  • Measured serum thyroid hormones and binding proteins in 38 active TB patients and 29 controls.
  • Assessed changes before and during 10 days of TB therapy.
  • Included measurements of triiodothyronine (T3), thyroxine (T4), thyrotropin (TSH), TBG, transthyretin (TTR), and albumin.

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Main Results:

  • Antituberculosis therapy increased TBG and decreased T3 resin uptake (T3RU), indicating increased binding.
  • Low T3 levels were common in untreated TB patients, consistent with non-thyroidal illness.
  • T3, TTR, and albumin increased towards normal with therapy, acting as negative acute phase reactants.
  • Rifampin and isoniazid combination therapy significantly increased T3 and T3RU in controls.

Conclusions:

  • TB patients show altered thyroid hormone binding, often normal or increased, despite low T3.
  • Chemotherapy, particularly rifampin, enhances thyroid hormone binding by increasing TBG.
  • Findings clarify thyroid function dynamics during TB treatment.