Related Experiment Video
Updated: Oct 3, 2026

Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology
Published on: August 18, 2014
S-100-immunoreactive nerves in the urinary bladder of the rat
1Evolutionary and Comparative Biology Department, University of Naples, Italy.
Abstract:
The innervation of the rat urinary bladder was investigated by light microscopy with use of S-100 antiserum and the peroxidase-antiperoxidase immunohistochemical technique according to Sternberger. The S-100 protein, a marker for myelinated nervous fibers, was mostly present in the muscle coat and the adventitia at the base of the bladder. Myelinated fibers were not observed in the epithelial layer, nor were ganglia found in the bladder wall. No differences in the amount and distribution of nerve fibers were found in full and empty bladders. Results were correlated with the analysis of the whole nervous component conducted by Ag staining according to Linder.
Related Concept Videos
Urinary Bladder
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
The Micturition Reflex
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating urine...
Anatomy of the Genitourinary System II: Bladder and Urethra

