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Coeliac disease in adults

G R Corazza1, G Gasbarrini

  • 1University of L'Aquila, Italy.

Bailliere'S Clinical Gastroenterology
|June 1, 1995
PubMed
Summary

Coeliac disease, an autoimmune disorder, involves small intestine damage and nutrient malabsorption. Early diagnosis and a strict gluten-free diet are crucial for managing even silent forms and preventing complications.

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Area of Science:

  • Gastroenterology
  • Immunology
  • Clinical Medicine

Background:

  • Coeliac disease is a chronic autoimmune disorder affecting the small intestine.
  • It leads to villous atrophy, impairing nutrient absorption.
  • Recent advances have improved understanding of adult coeliac disease, including subclinical forms.

Purpose of the Study:

  • To highlight the changing perspectives on coeliac disease diagnosis and epidemiology.
  • To emphasize the importance of early diagnosis and treatment for all forms of coeliac disease.
  • To advocate for systematic screening in at-risk populations.

Main Methods:

  • Review of current knowledge on adult coeliac disease.
  • Discussion of diagnostic challenges, including subclinical presentations.
  • Recommendation of non-invasive antibody screening tests (anti-gliadin, anti-endomysium).

Main Results:

  • Coeliac disease prevalence is estimated at approximately 1 in 300 adults.
  • Subclinical and silent forms are increasingly recognized.
  • A strict gluten-free diet is protective against disease complications.

Conclusions:

  • Early diagnosis and treatment of coeliac disease, including subclinical cases, are vital.
  • Systematic screening using antibody tests is recommended for at-risk groups.
  • Further research may identify additional associated conditions.

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