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Changes in renal function with aging among Japanese

T Hosoya1, R Toshima, K Icida

  • 1Second Department of Internal Medicine, Jikei University School of Medicine, Tokyo.

Internal Medicine (Tokyo, Japan)
|June 1, 1995
PubMed
Summary
This summary is machine-generated.

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Aging and sex impact kidney function. Serum creatinine rises with age and is higher in males, while urinary creatinine decreases with age, especially in men. Kidney function declines with age, with Japanese elderly showing lower creatinine clearance than Westerners.

Area of Science:

  • Nephrology
  • Gerontology
  • Clinical Biochemistry

Background:

  • Renal function is crucial for overall health and drug metabolism.
  • Aging and sexual dimorphism are known to influence physiological parameters.
  • Understanding age-related and sex-specific changes in renal function is vital for accurate clinical assessments.

Purpose of the Study:

  • To investigate the relationship between aging, sexual differences, and renal function in Japanese inpatients.
  • To assess changes in serum creatinine, urinary creatinine excretion, and creatinine clearance with aging.
  • To compare renal function markers between males and females and across different age groups.

Main Methods:

  • Cross-sectional study involving 329 inpatients without pre-existing renal disease.

Related Experiment Videos

  • Measurement of serum creatinine, urinary creatinine excretion, and serum beta 2-microglobulin.
  • Calculation of creatinine clearance (Cer) and correction for body surface area.

    • Main Results:

    • Serum creatinine levels increased with aging and were significantly higher in males.
    • Urinary creatinine excretion decreased with aging, with a more pronounced decline in males.
    • Creatinine clearance decreased significantly with aging, irrespective of body surface area, and was lower in aged Japanese compared to Western populations.
    • Serum beta 2-microglobulin levels increased with aging.

    Conclusions:

    • Renal function declines with aging, with notable sex differences in creatinine levels and excretion.
    • Age-related decline in renal function is significant in the Japanese population.
    • Findings highlight the need for age- and sex-specific considerations in clinical testing and drug administration for the elderly in Japan.