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[The markers of hepatitis B, C and D viral infection in multiply transfused patients]

I S Bocşan1, A Neamţu, A Rădulescu

  • 1Universitatea de Medicină şi Farmacie Iuliu Haţieganu, Cluj-Napoca.

Bacteriologia, Virusologia, Parazitologia, Epidemiologia (Bucharest, Romania : 1990)
|April 1, 1995
PubMed

Insights

Hepatitis B, C, and D viral markers are highly prevalent in multi-transfused patients in Cluj-Napoca, with frequent dual HBV and HCV infections. HDV infection is rare in HBV patients, contrary to prior findings.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Transfusion Medicine

Background:

  • Multi-transfused patients are at increased risk of viral hepatitis.
  • Hepatitis B virus (HBV), Hepatitis C virus (HCV), and Hepatitis D virus (HDV) pose significant health concerns.
  • Understanding seroprevalence in specific populations is crucial for public health strategies.

Purpose of the Study:

  • To determine the seroprevalence of HBV, HCV, and HDV markers.
  • To assess the frequency of co-infections (HBV and HCV).
  • To investigate HDV prevalence in HBV-infected patients within the Cluj-Napoca multi-transfused population.

Main Methods:

  • Serum samples from 105 multi-transfused patients (children, adults, hemodialysis patients) were analyzed.
  • Automated ELISA kits were used to detect HBsAg, anti-HBs, total anti-HBc, anti-HCV, and total anti-HDV.
  • Patient groups included children, adults, and chronically hemodialyzed individuals.

Main Results:

  • High seroprevalence of HCV (16-79%) and HBV (32-89%) was observed across patient groups.
  • Dual HBV and HCV infections were frequent (4-84.2%).
  • HDV infection markers were found in only 4.25% of HBV-infected hemodialysis patients; none in children or adults.

Conclusions:

  • Viral hepatitis marker prevalence is high in multi-transfused patients in the Cluj area.
  • Dual HCV and HBV infection is common, particularly in adults.
  • Low prevalence of HDV in HBV-infected patients contrasts with previous reports.
Abstract

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