Related Experiment Videos
The molecular basis of fragile sites in human chromosomes
1Department of Cytogenetics and Molecular Genetics, Women's and Children's Hospital, Adelaide, Australia.
Current Opinion in Genetics & Development
|June 1, 1995
Abstract:
Fragile sites on chromosomes have been classified into a number of groups according to their frequency and the conditions required to induce them. A number of the rare folate-sensitive fragile sites have been characterized and shown to be amplified methylated CCG trinucleotide repeats. One common fragile site has been partly characterized and appears to be a region of fragility, rather than a single site.