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Adrenalectomy does not prevent the ability of 8-OH-DPAT to decrease the ejaculatory threshold in male rats

J Vega-Matuszczyk1, S Ahlenius, P Eneroth

  • 1Department of Psychology, University of Göteborg, Sweden.

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
|June 1, 1995
PubMed
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The drug 8-OH-DPAT reduces the ejaculatory threshold in male rats, regardless of adrenal gland removal. This effect on sexual behavior is independent of adrenal secretions.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Male sexual behavior

Background:

  • The drug 8-OH-DPAT is known to affect serotonin receptors and has shown effects on sexual behavior.
  • Adrenal hormones, such as corticosterone, can influence various physiological processes, including reproductive functions.

Purpose of the Study:

  • To investigate the role of adrenal secretions in mediating the effects of 8-OH-DPAT on male rat sexual behavior.
  • To determine if adrenalectomy alters the response to 8-OH-DPAT regarding the ejaculatory threshold.

Main Methods:

  • Male rats underwent either adrenalectomy or sham surgery.
  • Animals were treated with 8-OH-DPAT (0.25 mg/kg SC) 15 minutes prior to behavioral testing.
  • Sexual behavior parameters, including mounts, intromissions, ejaculation latency, and postejaculatory interval, were recorded.

Related Experiment Videos

  • Plasma corticosterone levels were measured to confirm adrenalectomy.

    • Main Results:

    • 8-OH-DPAT significantly decreased the ejaculatory threshold in both adrenalectomized and sham-operated rats.
    • Treatment with 8-OH-DPAT reduced the number of mounts and intromissions preceding ejaculation and decreased ejaculation latency in both groups.
    • Adrenalectomy itself did not alter any measured aspect of male rat sexual behavior.
    • Plasma corticosterone levels were significantly lower in adrenalectomized rats, confirming successful surgery.

    Conclusions:

    • The decrease in ejaculatory threshold induced by 8-OH-DPAT is not dependent on the presence of adrenal secretions.
    • The known effects of 8-OH-DPAT on adrenal hormones do not contribute to its pro-ejaculatory action in male rats.
    • These findings suggest that the mechanism of 8-OH-DPAT's effect on sexual behavior is independent of the adrenal axis.