[Biotechnology manufacture as a possible source of environmental pollution and a risk factor for human health]

The biotechnology-oriented quantitative criteria and a plan of primary sanitary hygienic evaluation of pathogenicity of microorganisms-producers were first established. New evidence of the negative effects of strains-producers on microbiocenosis and self-purification of soils and reservoirs were obtained. The requirement of an all-round hygienic assessment of microorganisms-producers consisting of two mandatory steps, i.e. the primary sanitary hygienic evaluation of pathogenicity of strains and the investigation of effects of these microorganisms on microbiocenosis and soil and reservoir self-purification has been substantiated.