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Leukocyte hexokinase activity in aging and Alzheimer disease
P G Antuono1, J Ravanelli-Meyer, K Nicholson
1Department of Neurology, Medical College of Wisconsin, Milwaukee 53226, USA.
Dementia (Basel, Switzerland)
|July 1, 1995
Abstract:
We determined the effects of clinical variables on hexokinase (HK) activity in leukocytes from Alzheimer's disease (AD) patients and controls. Age accounted for 51% of the variance in HK activity in the young and 23% in the old. Duration of illness in both familial and sporadic AD accounted for HK levels by 32 and 38%, respectively. Hexokinase activity increases with age and does not discriminate between familial and sporadic AD.