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Diffuse laminar endocervical glandular hyperplasia

R Maruyama1, S Nagaoka, K Terao

  • 1Department of Laboratory Medicine, Shimane Medical University, Izumo, Japan.

Pathology International
|April 1, 1995
PubMed
Summary

A rare case of diffuse laminar endocervical glandular hyperplasia, a pseudoneoplastic lesion, is presented. This condition, characterized by gland proliferation without atypia, requires careful differential diagnosis from adenocarcinoma.

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Area of Science:

  • Gynecologic Pathology
  • Cervical Pathology
  • Glandular Lesions

Background:

  • Endocervical glandular lesions encompass a spectrum from reactive changes to malignancy.
  • Pseudoneoplastic lesions are common, but diffuse laminar endocervical glandular hyperplasia is exceptionally rare.
  • Accurate diagnosis is crucial for appropriate patient management.

Observation:

  • A 54-year-old woman presented with a 7-year history of watery vaginal discharge.
  • A hysterectomy specimen revealed a diffuse, laminar proliferation of hyperplastic endocervical glands.
  • The lesion was well-demarcated from the stroma, with absent nuclear atypia and mild inflammation.

Findings:

  • Microscopic examination confirmed diffuse laminar endocervical glandular hyperplasia.

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  • Immunohistochemical staining for carcinoembryonic antigen was negative.
  • The absence of significant nuclear atypia and negative tumor markers aid in distinguishing it from adenocarcinoma.

    • Implications:

    • This case highlights the importance of recognizing rare pseudoneoplastic lesions in the cervix.
    • Differential diagnosis should include well-differentiated adenocarcinoma, necessitating careful histological evaluation.
    • Understanding this entity contributes to the comprehensive classification of endocervical glandular abnormalities.