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Gastrointestinal metastases from malignant melanoma
N Ricaniadis1, M M Konstadoulakis, D Walsh
1Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
Surgical Oncology
|January 1, 1995
Summary
Surgery for gastrointestinal (GI) metastatic melanoma offers significant survival benefits. Complete resection of GI metastases, especially without other disease, leads to improved long-term outcomes and palliation.
Area of Science:
- Oncology
- Gastroenterology
- Surgical Oncology
Background:
- Metastatic melanoma frequently involves the gastrointestinal (GI) tract.
- Clinical presentations include anemia, abdominal pain, nausea, and vomiting.
Purpose of the Study:
- To evaluate the outcomes of surgical intervention for GI metastases from melanoma.
- To determine the impact of surgical resection on patient survival and palliation.
Main Methods:
- Retrospective analysis of 68 patients with GI metastatic melanoma treated between 1980-1992.
- Categorization of patients based on surgical eligibility, procedure type, and presence of other metastases.
Main Results:
- Complete resection of GI metastases was achieved in 47% of surgically treated patients.
- Median survival was significantly higher for patients with complete resection (27.6 months) compared to bypass (1.9 months) or incomplete resection (5.1 months).
- 5-year survival was 28.3% for patients with complete resection and no other disease.
Conclusions:
- Surgical intervention for GI metastatic melanoma is justified.
- Complete resection of metastatic disease offers extended palliation and improved survival outcomes.