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Growth-phase regulation of plasmid virulence genes in Salmonella
D G Guiney1, S Libby, F C Fang
1Dept of Medicine 0640, UCSD School of Medicine, La Jolla, CA 92093-0640, USA.
Trends in Microbiology
|July 1, 1995
Abstract:
Virulence genes in the genus Salmonella are regulated by growth phase and by environmental signals, which allows a sequential program of expression during infection. Conditions that promote the expression of loci required in systemic infection, including the plasmid-encoded spv genes, are the opposite of the factors that induce genes involved in the invasion of epithelial cells in the gastrointestinal tract.