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A composite skin substitute (graftskin) for surgical wounds. A clinical experience
W H Eaglstein1, M Iriondo, K Laszlo
1Department of Dermatology, University of Miami School of Medicine, FL 33101, USA.
Background:
Bioengineered skin substitutes offer tissue replacement without requiring a donor site and might produce better healing.
Objective:
To evaluate the recipient's response to grafting a bioengineered skin equivalent onto acute surgical wounds.
Methods:
Graftskin, which is made of: 1) a bovine collagen matrix containing human fibroblasts, and 2) an overlying sheet of stratified human epithelium, was grafted onto the excision sites of 15 patients.
Results:
Blood and cell studies for toxicity were negative. Graftskin proved easy to handle, and a typical clinical appearance of the skin substitute during "take" was detected. Compared with expectations improved healing occurred. Twelve of 15 patients had initial clinical takes.
Conclusion:
Graftskin was not clinically rejected and was not toxic. It often appeared to take and produced better than expected healing.