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Related Experiment Videos

Cytokine expression in chronic inflammatory disease

F M Brennan1, R N Maini, M Feldmann

  • 1Mathilda & Terence Kennedy Institute of Rheumatology, Hammersmith, London, UK.

British Medical Bulletin
|April 1, 1995
PubMed
Summary

Tumor necrosis factor alpha (TNF alpha) is a key molecule in rheumatoid arthritis (RA) pathology. Neutralizing TNF alpha with antibodies has proven effective in clinical trials for RA patients.

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Area of Science:

  • Immunology
  • Rheumatology
  • Molecular Biology

Background:

  • Chronic inflammatory diseases like rheumatoid arthritis (RA) involve complex cytokine dysregulation.
  • The synovial joint tissue is a primary site affected by RA pathology.

Purpose of the Study:

  • To investigate the role of cytokine production in RA pathogenesis.
  • To identify pivotal molecules contributing to synovial joint inflammation in RA.

Main Methods:

  • Review of studies on cytokine expression in RA over 9 years.
  • Identification of specific cytokines implicated in RA pathology.

Main Results:

  • Tumor necrosis factor alpha (TNF alpha) was identified as a pivotal cytokine in RA.
  • Clinical trials using anti-TNF alpha antibodies demonstrated efficacy in RA patients.

Conclusions:

  • TNF alpha plays a critical role in the disease process of rheumatoid arthritis.
  • Targeting TNF alpha with neutralizing antibodies is a successful therapeutic strategy for RA.

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