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The role of T-cells in inflammatory kidney disease
1Department of Adult Nephrology, Monash Medical Centre, Clayton, Victoria, Australia.
The fundamental role of cell-mediated immunity in inflammatory disease of the kidney has been established for some time. This review focusses on the recent advances in our understanding of the role of T-cells in the pathogenesis both of glomerulonephritis and interstitial nephritis. In particular, the increasing experimental evidence for a functional role for T-cells in promoting disease initiation and progression is examined. The ever increasing variety of T-cell-effector functions and their relevance are also discussed.
The fundamental role of cell-mediated immunity in inflammatory disease of the kidney has been established for some time. This review focusses on the recent advances in our understanding of the role of T-cells in the pathogenesis both of glomerulonephritis and interstitial nephritis. In particular, the increasing experimental evidence for a functional role for T-cells in promoting disease initiation and progression is examined. The ever increasing variety of T-cell-effector functions and their relevance are also discussed.