Skeletal lesions in early congenital syphilis (a review of 86 cases)
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M Ghadouane1, B S Benjelloun, L Elharim-Roudies
1Infectious Diseases Department, Pediatric Teaching Hospital Ibn Sina-Rabat, Morocco.
Abstract:
Early congenital syphilis is still common in Morocco, where it causes a large number of stillbirths and neonatal deaths. Over the last 16 years, we managed 86 cases of congenital syphilis in infants aged one day to four months. Multiple organs were affected in half the patients. Skeletal lesions were found in 65% of patients, Wimberger's sign in nearly 20% (17/86), and pseudoparalysis in 23%. The significance of the skeletal lesions often seen in congenital syphilis in Morocco is emphasized.
Insights
Congenital syphilis remains a significant threat in Morocco, leading to infant mortality. Skeletal lesions, including Wimberger
Area of Science:
- Pediatrics
- Infectious Diseases
- Public Health
Background:
- Early congenital syphilis presents a persistent public health challenge in Morocco.
- The condition contributes significantly to stillbirths and neonatal mortality rates.
Purpose of the Study:
- To analyze the clinical presentation and outcomes of early congenital syphilis in Moroccan infants.
- To highlight the prevalence and importance of skeletal manifestations.
Main Methods:
- Retrospective case series analysis of 86 infants diagnosed with congenital syphilis.
- Infants aged one day to four months were managed over a 16-year period.
- Clinical data, including organ involvement and skeletal findings, were reviewed.
Main Results:
- Half of the infants presented with multiple organ involvement.
- Skeletal lesions were observed in 65% of cases.
- Specific skeletal findings included Wimberger's sign (20%) and pseudoparalysis (23%).
Conclusions:
- Congenital syphilis frequently causes significant skeletal abnormalities in infants in Morocco.
- Early diagnosis and management are crucial to mitigate severe outcomes.
- Skeletal lesions are a key indicator of congenital syphilis severity in this region.