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Zygomycotic lung abscess: a case report

J S Chen1, C C Lin, S L Lin

  • 1Department of Internal Medicine, Veterans General Hospital-Kaohsiung, Kaohsiung, Taiwan, R.O.C.

Zhonghua Yi Xue Za Zhi = Chinese Medical Journal; Free China Ed
|August 1, 1995
PubMed
Summary
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Zygomycosis, a rare fungal infection, can be fatal. This case highlights a lung abscess caused by Rhizopus spp. in a healthy individual, successfully treated with reduced amphotericin B dosage.

Area of Science:

  • Mycology
  • Infectious Diseases

Background:

  • Zygomycosis is a severe fungal infection caused by Zygomycetes, often fatal.
  • Risk factors include diabetes mellitus, uremia, leukemia, and deferoxamine use.
  • Pulmonary zygomycosis commonly affects immunocompromised patients, such as those with granulocytopenia or on corticosteroids.

Observation:

  • This report details a case of a previously healthy farmer with a left upper lung abscess.
  • The abscess was caused by Rhizopus spp., a fungus belonging to the order Mucorales.
  • The patient received 948 mg of amphotericin B but could not tolerate the planned 2,000 mg due to side effects.

Findings:

  • Despite incomplete treatment, the patient recovered without fever or cough.
  • Chest X-rays showed satisfactory improvement over three months.

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Implications:

  • This case suggests that successful outcomes for pulmonary zygomycosis may be achievable with reduced amphotericin B dosages in select patients.
  • It underscores the importance of considering zygomycosis even in seemingly healthy individuals.
  • Further research into optimal treatment durations and dosages for zygomycosis is warranted.