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Implantable bone substitute materials

J R Hanft1, R W Sprinkle, M S Surprenant

  • 1HealthSouth Larkin Podiatric Residency Program, HealthSouth Larkin Hospital, South Miami, Florida, USA.

Clinics in Podiatric Medicine and Surgery
|July 1, 1995
PubMed
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This article reviews bone substitute materials, which can replace or augment autografts in bone repair. Different materials offer unique properties for specific applications, with future developments also explored.

Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Regenerative Medicine

Background:

  • Bone defects and the limitations of autografts necessitate the development of bone substitute materials.
  • Autografts remain a gold standard but have donor site morbidity and limited availability.
  • Allografts and synthetic materials offer alternatives with varying degrees of success.

Purpose of the Study:

  • To provide a comprehensive overview of current bone substitute materials.
  • To discuss the properties and applications of various bone graft alternatives.
  • To explore emerging trends and future directions in bone regeneration.

Main Methods:

  • Literature review of existing bone substitute materials.
  • Analysis of material properties, including biocompatibility, osteoconductivity, and osteoinductivity.

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  • Discussion of clinical applications and outcomes.

    • Main Results:

    • Various materials like ceramics, polymers, and composites are used as bone substitutes.
    • Each material possesses distinct characteristics influencing its suitability for specific orthopedic applications.
    • Bone substitutes can be used independently or in conjunction with autografts.

    Conclusions:

    • Bone substitute materials offer promising alternatives to autografts for bone defect repair.
    • Material selection should be guided by specific clinical needs and desired outcomes.
    • Continued research and development are crucial for advancing bone regeneration therapies.