Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Integrins in tumour development and spread

M Pignatelli1, G Stamp

  • 1Department of Histopathology, Royal Postgraduate Medical School, London.

Cancer Surveys
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Glioblastoma adaptation traced through decline of an IDH1 clonal driver and macro-evolution of a double-minute chromosome.

Annals of oncology : official journal of the European Society for Medical Oncology·2015
Same author

Regional specificity of synaptic plasticity deficits in a knock-in mouse model of DYT1 dystonia.

Neurobiology of disease·2014
Same author

Whole-genome sequencing reveals complex mechanisms of intrinsic resistance to BRAF inhibition.

Annals of oncology : official journal of the European Society for Medical Oncology·2014
Same author

Patupilone in patients with pretreated metastatic/locally recurrent colorectal cancer: results of the Phase II CINATRA trial.

Investigational new drugs·2013
Same author

Identifying a healthy oral microbiome through metagenomics.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2012
Same author

Characterization of a novel oral glucocorticoid system and its possible role in disease.

Journal of dental research·2011
Same journal

Future directions: bladder cancer.

Cancer surveys·2004
Same journal

Radiotherapy and chemotherapy for invasive bladder cancer.

Cancer surveys·2004
Same journal

The role of surgery in the multimodality treatment of bladder cancer.

Cancer surveys·2004
Same journal

Clonal development of bladder cancer and its relevance to the clinical potential of HLA antigen and TP53 based gene therapy.

Cancer surveys·2004
Same journal

Clinical evaluation of immunotherapy: are there differences between papillary and flat in situ bladder cancer?

Cancer surveys·2004
Same journal

Molecular biological changes in bladder cancer.

Cancer surveys·2004
See all related articles

Investigating integrin receptors in carcinomas enhances understanding of cancer and treatment evaluation. Further large-scale studies are needed to confirm their role as prognostic indicators and in predicting metastasis.

Area of Science:

  • Oncology
  • Cell Biology
  • Molecular Medicine

Background:

  • Integrin receptors play a role in cellular processes relevant to cancer.
  • Understanding integrin expression and function in carcinomas is crucial for advancing cancer research.

Purpose of the Study:

  • To explore the significance of integrin receptor expression and function in carcinomas.
  • To assess the potential of integrins as prognostic indicators and predictors of metastasis.
  • To guide future research directions for clinical applications and therapeutic developments.

Main Methods:

  • Analysis of integrin receptor expression and function in carcinoma cells.
  • Evaluation of correlations between integrin profiles and tumor characteristics.
  • Review of existing literature and identification of research gaps.

Related Experiment Videos

Main Results:

  • Integrin research deepens the understanding of the malignant process.
  • Current data on integrins as prognostic markers are limited by small study cohorts.
  • Integrin profiles show potential but require further validation.

Conclusions:

  • Further investigation into integrin receptor expression and function in carcinomas is warranted.
  • Large-scale, multicenter studies are necessary to establish the clinical significance of integrins in cancer prognosis and treatment response.
  • Development of reagents for integrin detection in archival human tumor specimens is recommended for future research.