Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Desmosomes and cancer

D R Garrod1

  • 1Cancer Research Campaign Epithelial Morphogenesis Research Group, School of Biological Sciences, University of Manchester.

Cancer Surveys
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Desmosomes, crucial for cell adhesion, are downregulated in some head and neck cancers, suggesting a role in suppressing metastasis. Their presence in colorectal carcinoma raises questions about tumor invasion mechanisms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative enzymology of native and recombinant house dust mite allergen Der p 1.

Allergy·2009
Same author

Interactions between mature Der p 1 and its free prodomain indicate membership of a new family of C1 peptidases.

Allergy·2007
Same author

Protein kinase C alpha expression in normal breast, ductal carcinoma in situ and invasive ductal carcinoma.

European journal of cancer (Oxford, England : 1990)·2004
Same author

The detection of IgG and IgA autoantibodies to desmocollins 1-3 by enzyme-linked immunosorbent assays using baculovirus-expressed proteins, in atypical pemphigus but not in typical pemphigus.

The British journal of dermatology·2004
Same author

Altered expression of desmosomal components in high-grade squamous intraepithelial lesions of the cervix.

Virchows Archiv : an international journal of pathology·2003
Same author

Desmosomal adhesion regulates epithelial morphogenesis and cell positioning.

Nature cell biology·2001
Same journal

Future directions: bladder cancer.

Cancer surveys·2004
Same journal

Radiotherapy and chemotherapy for invasive bladder cancer.

Cancer surveys·2004
Same journal

The role of surgery in the multimodality treatment of bladder cancer.

Cancer surveys·2004
Same journal

Clonal development of bladder cancer and its relevance to the clinical potential of HLA antigen and TP53 based gene therapy.

Cancer surveys·2004
Same journal

Clinical evaluation of immunotherapy: are there differences between papillary and flat in situ bladder cancer?

Cancer surveys·2004
Same journal

Molecular biological changes in bladder cancer.

Cancer surveys·2004
See all related articles

Area of Science:

  • Oncology
  • Cell Biology
  • Pathology

Background:

  • Desmosomes are cell adhesion structures critical for tissue integrity.
  • Expression patterns of desmosomes vary across different carcinoma types.
  • Desmosomes may play a role in suppressing tumor invasion and metastasis.

Purpose of the Study:

  • To investigate the role of desmosome expression in different cancer types.
  • To explore potential mechanisms of tumor invasion in carcinomas with intact desmosomes.
  • To evaluate desmoplakins as diagnostic markers for carcinomas.

Main Methods:

  • Immunohistochemical analysis of desmosome and desmoplakin expression in various carcinomas.
  • Comparison of desmosome expression in primary tumors and metastatic lesions.

Related Experiment Videos

  • Literature review on desmosome function in cancer.

    • Main Results:

    • Downregulated desmosome expression observed in poorly differentiated head and neck squamous cell carcinomas and transitional cell carcinomas.
    • No downregulation of desmosomes found in colorectal carcinoma.
    • Desmosomes, desmoplakins, vimentin, and keratin were identified as markers to distinguish between meningiomas and metastatic carcinomas.

    Conclusions:

    • Desmosomes may function as invasion and metastasis suppressors in certain head and neck cancers.
    • Tumor invasion in colorectal carcinoma with intact desmosomes might involve temporary modulation of adhesive affinity.
    • Desmoplakin antibodies are reliable immunohistochemical markers for carcinoma diagnosis and distinguishing intracranial tumors.