Up-regulation of resistance-related proteins in human lung tumors with poor vascularization

¹Department of Radiology and Oncology, Tartu University, Estonia.

|September 1, 1995

Abstract:

Microvessel density was investigated by immunostaining endothelial cells for factor VIII antigen in 84 non-small cell lung carcinomas and compared with the expression of several resistance-related proteins. Glutathione S-transferase-pi, thymidylate synthase, metallothionein and, with limitations, P-glycoprotein were overexpressed in tumors with poor vascularization.

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Abstract:

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