Effect of kainate-induced seizure activity on the polyamine interconversion pathway in juvenile rat brain

The activity of the polyamine interconversion pathway was investigated in the hippocampus and piriform cortex after systemic KA administration in juvenile rats. Pretreatment of 7-day-old rats with the polyamine oxidase inhibitor, MDL 72527, induced a similar accumulation of N-acetylspermidine and N-acetylspermine in control and kainate-treated animals. The results indicate that KA-induced seizure activity has no effect on the polyamine interconversion pathway in developing rat brain.