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Polymorphonuclear leukocyte elastase levels in patients with Behçet's disease
1Department of Biochemistry, Faculty of Medicine, Karadeniz Technical University, Tip Fak, Biyokimya, ABD, Trabzon, Turkey.
Summary
Polymorphonuclear (PMN) elastase shows significantly higher levels in Behçet's disease patients compared to healthy individuals. Elevated PMN elastase may serve as a valuable biochemical marker for diagnosing Behçet's disease and monitoring treatment effectiveness.
Area of Science:
- Rheumatology
- Immunology
- Biochemistry
Background:
- Behçet's disease is a chronic, multisystem inflammatory disorder of unknown cause.
- Increased polymorphonuclear leukocyte (PMN) activity is a known feature of Behçet's disease.
Purpose of the Study:
- To investigate polymorphonuclear (PMN) elastase as a potential biochemical marker for Behçet's disease.
- To assess the diagnostic and therapeutic monitoring utility of PMN elastase levels.
Main Methods:
- Evaluated PMN elastase, ESR, protein electrophoresis, immunoglobulins, and complement levels in 42 Behçet's disease patients and 40 healthy controls.
- Compared PMN elastase levels between patients and controls, and between acute and remission phases in patients.
Main Results:
- Mean PMN elastase levels were significantly higher in Behçet's disease patients (244.2 µg/l) than in healthy subjects (44.3 µg/l) (P < 0.001).
- PMN elastase levels were higher during the acute phase (321.5 µg/l) compared to remission (159 µg/l) (P < 0.001).
Conclusions:
- Polymorphonuclear (PMN) elastase is a promising biochemical marker for the diagnosis of Behçet's disease.
- PMN elastase levels can aid in controlling and monitoring therapy for patients with Behçet's disease.
