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Updated: Aug 10, 2026
13:27
Generation of Human CD40-activated B cells
Published on: October 17, 2009
CD40-CD40 ligand (CD40L) interactions and X-linked hyperIgM syndrome (HIGMX-1)
N Ramesh1, T Morio, R Fuleihan
1Division of Immunology, Children's Hospital, Boston, Massachusetts 02115, USA.
Clinical Immunology and Immunopathology
|September 1, 1995
Summary
The interaction between CD40 and CD40L is crucial for B cell isotype switching. Defects in this pathway cause hyperIgM syndrome, highlighting its importance in adaptive immunity.
Area of Science:
- Immunology
- Molecular Biology
Background:
- B cell isotype switching is essential for adaptive immunity.
- The CD40-CD40L pathway is a key regulator of B cell function.
Purpose of the Study:
- To review the critical role of CD40-CD40L interactions in B cell isotype switching.
- To discuss the signaling mechanisms and regulatory control of CD40L expression.
Main Methods:
- Review of clinical data from X-linked hyperIgM syndrome patients.
- Analysis of findings from CD40-deficient mouse models.
- Discussion of molecular signaling and gene regulation.
Main Results:
- Patients with CD40L mutations (X-linked hyperIgM syndrome) exhibit impaired isotype switching.
- CD40-deficient mice fail to undergo T-cell-dependent isotype switching.
- CD40 signaling and CD40L expression are tightly regulated.
Conclusions:
- The CD40-CD40L axis is indispensable for effective B cell isotype switching.
- Understanding CD40 signaling and CD40L regulation is vital for immune therapies.
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