Related Experiment Video

Updated: Aug 11, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

A multicenter, randomized, double-blind, placebo-controlled, two-year trial to study the effect of nitrendipine on

M Barenbrock1, U Colmorgen, E Firschka

  • 1Department of Medicine, University of Berlin (Charité), Germany.

Clinical Nephrology
|June 1, 1995
PubMed

Insights

Nitrendipine did not significantly alter kidney function in renal transplant recipients. However, it effectively lowered blood pressure in hypertensive patients, while normotensive patients experienced a rise in blood pressure.

Area of Science:

  • Nephrology
  • Transplantation Immunology
  • Pharmacology

Background:

  • Renal transplantation is a critical treatment for end-stage renal disease.
  • Maintaining optimal blood pressure is crucial for graft survival post-transplantation.
  • The role of specific antihypertensive agents like nitrendipine in renal transplant recipients requires further investigation.

Purpose of the Study:

  • To evaluate the effect of nitrendipine on kidney function in renal transplant recipients.
  • To assess the impact of nitrendipine on blood pressure control in both normotensive and hypertensive transplant patients.
  • To determine the incidence of graft failure in relation to nitrendipine treatment.

Main Methods:

  • A multicenter, randomized, double-blind, placebo-controlled trial was conducted.
  • Renal transplant recipients were stratified into normotensive and hypertensive groups.
  • Patients received either nitrendipine or placebo for 104 weeks, with additional antihypertensives used if necessary.

Main Results:

  • No significant changes in renal transplant function were observed in either group after 12 months.
  • Nitrendipine significantly decreased blood pressure in the hypertensive group.
  • Blood pressure increased significantly in the normotensive group treated with nitrendipine.
  • Graft failure occurred in 4 hypertensive patients but none in the normotensive group.

Conclusions:

  • Nitrendipine does not appear to significantly impact renal transplant function in the short term.
  • Careful blood pressure monitoring is essential in renal transplant recipients, particularly when using nitrendipine in normotensive individuals.
  • Further research is needed to understand the long-term effects and optimal use of nitrendipine in this population.

More Related Videos

Long-Term Continuous Measurement of Renal Blood Flow in Conscious Rats05:09

Long-Term Continuous Measurement of Renal Blood Flow in Conscious Rats

Published on: February 8, 2022

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

Related Concept Videos

Antihypertensive Drugs: Direct Renin Inhibitors01:25

Antihypertensive Drugs: Direct Renin Inhibitors

The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...