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Related Experiment Videos

Local and distant products from modularity

J J Jacobs1, R M Urban, J L Gilbert

  • 1Department of Orthopedic Surgery, Rush-Presbyterian-St Lukes Medical Center, Chicago, IL 60612, USA.

Clinical Orthopaedics and Related Research
|October 1, 1995
PubMed
Summary
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Corrosion products from hip implants can spread locally and distantly. Elevated metal levels in patients with moderate to severe implant corrosion were observed, though no overt toxicity was found.

Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Materials Science

Background:

  • Modular femoral hip prosthetics are widely used.
  • Corrosion at the head and neck junction is a known complication.
  • Understanding the distribution and effects of corrosion products is crucial for patient outcomes.

Purpose of the Study:

  • To characterize the local and distant distribution of corrosion products from modular femoral hip prosthetic components.
  • To correlate serum and urine metal levels with the degree of corrosion.
  • To investigate the potential mechanisms of implant wear and bone loss.

Main Methods:

  • Analysis of particulate corrosion products from retrieved implants and surrounding tissues.
  • Measurement of serum cobalt and urine chromium concentrations.

Related Experiment Videos

  • Correlation of metal levels with the observed degree of corrosion at the head and neck junction.

    • Main Results:

    • Identified metal oxides, metal chlorides, and chromium phosphate corrosion products on implants from multiple designs and manufacturers.
    • The most abundant solid corrosion product was an amorphous chromium orthophosphate hydrate-rich material.
    • Significantly elevated serum cobalt and urine chromium concentrations were found in patients with moderate to severe corrosion.

    Conclusions:

    • Solid corrosion products from modular femoral stems may contribute to articular wear and periprosthetic bone loss.
    • Systemic dissemination of metallic corrosion products is a concern, but overt systemic toxicity was not observed in this study.
    • Further research is needed to fully elucidate the long-term systemic effects of metallic corrosion products.