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Related Experiment Videos

Amphotericin-induced heart-rate decrease in children

M Levy1, J Domaratzki, G Koren

  • 1Division of General Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.

Clinical Pediatrics
|July 1, 1995
PubMed
Summary
This summary is machine-generated.

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Amphotericin B can cause significant, acute heart rate drops in children, sometimes leading to early treatment discontinuation. Healthcare providers should monitor for this serious adverse effect during therapy.

Area of Science:

  • Pediatric Pharmacology
  • Cardiovascular Toxicology
  • Antifungal Drug Adverse Effects

Background:

  • Amphotericin B is a critical antifungal agent used in pediatric medicine.
  • Adverse reactions to Amphotericin B can impact patient management and outcomes.
  • Understanding drug-induced cardiovascular effects is crucial for patient safety.

Purpose of the Study:

  • To describe and analyze acute decreases in heart rate associated with Amphotericin B administration in pediatric patients.
  • To identify the incidence and characteristics of this specific adverse event.
  • To compare patients experiencing heart rate drops with those who did not.

Main Methods:

  • Retrospective case series describing six pediatric patients with acute heart rate decreases during Amphotericin B therapy.

Related Experiment Videos

  • Comparison of affected patients with six age-matched controls who received Amphotericin B without this reaction.
  • Analysis of heart rate changes, timing of the reaction, and duration of therapy.

    • Main Results:

    • Six of 90 pediatric patients (6.7%) experienced acute, significant heart rate drops (mean from 104 to 62 bpm) temporally related to Amphotericin B.
    • The reaction occurred between day 3 and day 7 of therapy and persisted throughout infusions and for hours after.
    • Patients with heart rate drops received Amphotericin B for a significantly shorter duration (4.6 days) compared to controls (12.6 days).

    Conclusions:

    • Acute bradycardia is a potential, serious adverse effect of Amphotericin B in children.
    • This adverse event may necessitate early discontinuation of Amphotericin B therapy.
    • Awareness of this effect is vital for clinicians, especially in vulnerable pediatric patients.