Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

C-CAM expression in odontogenesis and tooth eruption

C Lüning1, J Wroblewski, B Obrink

  • 1Dept. Cell Mol. Biol., Medical Nobel Institute, Karolinska Institutet, Stockholm, Sweden.

Connective Tissue Research
|January 1, 1995
PubMed
Summary

The cell adhesion molecule C-CAM is crucial for tooth development and eruption. This study found C-CAM expression increases during key stages, suggesting its vital role in forming the junctional epithelium.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A fully capable pianist with a congenital bilateral agenesis of extensor pollicis brevis muscle.

Folia morphologica·2022
Same author

Immunoproteomic analysis of Trichinella spiralis larval crude antigens recognized by sera from patients with trichinellosis after treatment with albendazole.

Tropical biomedicine·2021
Same author

Morphology of sesamoid bones in keyboard musicians.

Folia morphologica·2020
Same author

Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo.

Journal of internal medicine·2011
Same author

Scandinavian Fellowship for Oral Pathology and Oral Medicine: statement on oral pathology and oral medicine in the European Dental Curriculum.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·2010
Same author

An impending crisis in the provision of histopathology expertise for mouse functional genomics.

The Journal of pathology·2008

Area of Science:

  • Cell Biology
  • Developmental Biology
  • Oral Biology

Background:

  • Cell adhesion molecules (CAMs) are critical for tissue development and organization.
  • The cell adhesion molecule C-CAM (also known as CEACAM1) has roles in various biological processes.
  • Understanding C-CAM's function during tooth development is essential for oral biology.

Purpose of the Study:

  • To investigate the spatiotemporal distribution of C-CAM during rat molar development, eruption, and junctional epithelium formation.
  • To elucidate the potential roles of C-CAM in odontogenesis and the formation of epithelial structures involved in tooth eruption.

Main Methods:

  • Immunohistochemistry was used to detect C-CAM protein distribution.
  • In situ hybridization was employed to analyze C-CAM messenger RNA (mRNA) localization.

Related Experiment Videos

  • These methods were applied to rat molar tissues at various developmental stages.

    • Main Results:

    • C-CAM was not detected during early odontogenesis, appearing at the late bell stage in odontoblasts and ameloblasts.
    • A localized increase in C-CAM (mRNA and protein) was observed in the reduced enamel epithelium before eruption.
    • High C-CAM levels were evident in the fusion zone during eruption and strongly expressed in the adult junctional epithelium.

    Conclusions:

    • C-CAM expression is temporally regulated during tooth development and eruption.
    • C-CAM likely plays a significant role in odontogenesis and the formation of the junctional epithelium.
    • The findings highlight C-CAM's importance in the development of oral epithelial structures.